Hydrogen promotes the activation of Cu, Zn superoxide dismutase in a rat corneal alkali-burn model
| Autor: | Takeshi Arima, Tsutomu Igarashi, Masaaki Uchiyama, Maika Kobayashi, Ikuroh Ohsawa, Akira Shimizu, Hiroshi Takahashi |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | International Journal of Ophthalmology, Vol 13, Iss 8, Pp 1173-1179 (2020) |
| Druh dokumentu: | article |
| ISSN: | 2222-3959 2227-4898 |
| DOI: | 10.18240/ijo.2020.08.01 |
| Popis: | AIM: To investigate the effects of hydrogen (H2) on Cu, Zn superoxide dismutase (SOD1) activation in a rat model of corneal alkali burn. METHODS: In each rat, one cornea was subjected to alkali exposure. Physiological saline (saline group) or H2-dissolved saline (H2 group) was instilled continuously on the cornea for 5min before and after alkali exposure. Inflammatory cells, neovascularization, and cytoplasmic SOD1 levels were evaluated immunohistochemically in enucleated eyes from both groups. Three-dimensional ultrastructural tissue changes in the eyes were analyzed using low-vacuum scanning electron microscopy. RESULTS: The numbers of both inflammatory and vascular endothelial cells were significantly reduced in the corneas of the H2 group (P |
| Databáze: | Directory of Open Access Journals |
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