A Placebo-Controlled Study of Raloxifene Added to Risperidone in Men with Chronic Schizophrenia
| Autor: | Mohammad-Reza Khodaie-Ardakani, Mohsen Khosravi, Razieh Zarinfard, Somayeh Nejati, Ali Mohsenian, Mina Tabrizi, Shahin Akhondzadeh |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Acta Medica Iranica, Vol 53, Iss 6 (2015) |
| Druh dokumentu: | article |
| ISSN: | 0044-6025 1735-9694 |
| Popis: | Selective estrogen receptor modulators (SERMs) such as raloxifene have already shown beneficial effects on negative, positive and general psychopathology symptoms in postmenopausal women with schizophrenia. The purpose of the present investigation was to assess the efficacy of raloxifene as an adjuvant agent in the treatment of men with chronic schizophrenia in an 8-week double-blind and placebo-controlled trial. In a randomized, double-blind and placebo-controlled study, forty-six male patients diagnosed with schizophrenia (DSM-IV-TR), were randomized to either raloxifene (120 mg/day) or placebo in addition to risperidone (6 mg/day) for eight weeks. The assessment was performed using the positive and negative symptom scale (PANSS) at baseline, and at weeks 2, 4, 6 and 8. Extrapyramidal symptom rating scale (ESRS) at baseline, weeks 1, 2, 4, 6, 8 and Hamilton depression rating scale (HDRS) at baseline and week 8 were also used to assess extrapyramidal symptoms and depression simultaneously. Forty-two patients completed the trial. The raloxifene group showed significantly greater improvement on the negative subscale (P |
| Databáze: | Directory of Open Access Journals |
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