The structural basis of the pH-homeostasis mediated by the Cl−/HCO3 − exchanger, AE2

Autor: Qing Zhang, Liyan Jian, Deqiang Yao, Bing Rao, Ying Xia, Kexin Hu, Shaobai Li, Yafeng Shen, Mi Cao, An Qin, Jie Zhao, Yu Cao
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-023-37557-y
Popis: Cells maintain a narrow physiological pH by exchanging intracellular bicarbonate for extracellular chloride. Here, authors determine the cryo-EM structures of human anion exchanger 2 (AE2) in five major operating states and one transitional state, to collectively demonstrate the process of pH-balancing.
Databáze: Directory of Open Access Journals