A pharmacodynamic investigation into the efficacy of osteoprotegerin during aseptic inflammation

Autor: Curl Linda, Barker Christopher, Dreyer Craig, Sampson Wayne
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Zdroj: Australasian Orthodontic Journal, Vol 28, Iss 2, Pp 219-224 (2012)
Druh dokumentu: article
ISSN: 2207-7480
DOI: 10.2478/aoj-2012-0020
Popis: Background: Osteoprotegerin (OPG), as an osteoclast antagonist, limits mineralised tissue resorption under physiological conditions. Previous work investigating OPG in a rat periodontal ligament (PDL) ankylosis model found no inhibitory effect on osteoclasts when OPG was administered at a dosage of 2.5mg/kg.1,2
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