| Autor: |
Keiko Oda‐Kawashima, Anna S. Sedukhina, Naoki Okamoto, Mariya lytvyn, Kimino Minagawa, Teppei Iwata, Toshio Kumai, Eri Sato, Eiichi Inada, Ayako Yamaura, Miki Sakamoto, Marta Roche‐Molina, Juan A. Bernal, Ko Sato |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
FEBS Open Bio, Vol 10, Iss 2, Pp 259-267 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2211-5463 |
| DOI: |
10.1002/2211-5463.12783 |
| Popis: |
Both inhalational and intravenous anesthetics affect myocardial remodeling, but the precise effect of each anesthetic on molecular signaling in myocardial remodeling is unknown. Here, we performed in silico analysis to investigate signaling alterations in cardiomyocytes induced by inhalational [sevoflurane (Sevo)] and intravenous [propofol (Prop)] anesthetics. Bioinformatics analysis revealed that nuclear factor‐kappa B (NF‐kB) signaling was inhibited by Sevo and promoted by Prop. Moreover, nuclear accumulation of p65 and transcription of NF‐kB‐regulated genes were suppressed in Sevo‐administered mice, suggesting that Sevo inhibits the NF‐kB signaling pathway. Our data demonstrate that NF‐kB signaling is inhibited by Sevo and promoted by Prop. As NF‐kB signaling plays an important role in myocardial remodeling, our results suggest that anesthetics may affect myocardial remodeling through NF‐kB. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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