The effect of aerobic endurance exercise on changes in heat shock protein 60 and insulin resistance in mice with type 2 diabetes
| Autor: | Mehrzad Shabani, Vahid Valipour-Dehnou, Mohammad Reza Tabandeh, Mahdieh Molanouri-Shamsi |
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| Jazyk: | perština |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Fiyz̤, Vol 26, Iss 3, Pp 273-281 (2022) |
| Druh dokumentu: | article |
| ISSN: | 1029-7855 2008-9821 |
| Popis: | Background: Heat shock protein 60 (HSP60) is considered as an indicator of mitochondrial stress and plays a role in modulating mitochondrial dysfunction. This study aimed to investigate the effect of aerobic endurance exercise on changes in heat shock protein 60 and insulin resistance in mice with type 2 diabetes. Materials and Methods: Thirty adult mice were randomly and equally divided into three groups: control (C), diabetic (D) and diabetic-exercise (DE). Diabetes was induced by intraperitoneal injection of Streptozotocin. Aerobic endurance training was performed five sessions per week for eight weeks. 48 hours after the last training session, glucose, insulin and HSP60 levels and insulin resistance index were measured. Results: Insulin and blood glucose levels and insulin resistance in group DE decreased significantly compared to group D (P |
| Databáze: | Directory of Open Access Journals |
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