Successful treatment of recurrent metastatic nasopharyngeal carcinoma with nivolumab: a case report
| Autor: | Yu. M. Bychkov, A. M. Mudunov, I. M. Gelfand, B. G. Pkheshkhova, O. D. Ryzhova, А. A. Akhundov, V. Z. Dobrokhotova, М. N. Narimanov |
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| Jazyk: | ruština |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Опухоли головы и шеи, Vol 9, Iss 2, Pp 99-104 (2019) |
| Druh dokumentu: | article |
| ISSN: | 2222-1468 2411-4634 |
| DOI: | 10.17650/2222-1468-2019-9-2-99-104 |
| Popis: | The study objective is to report a case of successful treatment of disseminated nasopharyngeal carcinoma with nivolumab.Materials and methods. A 22-year-old male patient was admitted to N.N. Blokhin National Medical Research Center of Oncology with a diagnosis of T3N3M1 stage IV nasopharyngeal carcinoma with bone metastasis. After a course of radical chemoradiotherapy, the patient was found to have cancer progression. Between September 2016 and July 2017, the patient received chemotherapy with 3 lines of drugs, but with no effect. We decided to initiate treatment with PD-1 inhibitors. The patient received nivolumab 3 mg/kg every 2 weeks between July 2017 and March 2018.Results. Positron emission tomography (September 2018) demonstrated no increased uptake of [18F]-fluorodeoxyglucose in earlier identified cancer foci. Since September 2018, the patient has been in persistent remission without any therapy.Conclusion. This case report demonstrates high efficacy of PD-1 inhibitors in the treatment of disseminated recurrent nasopharyngeal squamous cell carcinoma, resistant to standard radiotherapy and chemotherapy. |
| Databáze: | Directory of Open Access Journals |
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