A comparative structural analysis of sepiapterin reductase from Drosophila by homology modeling

Autor:	Kim Kiyoung, Song Keon-Hyoung, Yim Jeongbin
Jazyk:	angličtina
Rok vydání:	2015
Předmět:	drosophila sepiapterin reductase structure tetrahydrobiopterin (bh4) Crystallography QD901-999
Zdroj:	Pteridines, Vol 26, Iss 2, Pp 55-61 (2015)
Druh dokumentu:	article
ISSN:	0933-4807 2195-4720
DOI:	10.1515/pterid-2014-0017
Popis:	Sepiapterin reductase (SR) catalyzes the final steps of BH4 biosynthesis. Previously, a gene encoding SR has been cloned and characterized from a Drosophila cDNA library in vitro. The present study reports the identification of another SR gene in the Drosophila genome and the structural characteristics and differences of the two Drosophila SRs, using homology modeling analysis. Homology modeling of SRs for protein structure and function prediction showed that the two SRs have different surface electrostatic distributions and different shapes of the substrate (sepiapterin)-binding sites. These results provide valuable insight into the possibility of diverse functions of Drosophila SRs in vivo.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/55c53bf876ea4b178e7522425c703d26 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF