| Autor: |
Hye-Sun Lim, Byeong Cheol Moon, Gunhyuk Park |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Bangladesh Journal of Pharmacology, Vol 17, Iss 1 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1991-0088 |
| DOI: |
10.3329/bjp.v17i1.57472 |
| Popis: |
Cicadidae Periostracum has various pharmacological effects, including neuroprotective potential via nuclear receptor related-1 (NURR1) protein signaling. However, there are no studies on its antioxidative effect. The neuroprotective effect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced damage to dopaminergic neurons was evaluated and explored the mechanisms of its antioxidant action, focusing on nuclear factor E2-related factor 2 (Nrf2) in a mouse model of Parkinson's disease. We measured NURR1-related neurotrophic signaling and the levels of antioxidant factors in vitro and in vivo. The effects of Cicadidae Periostracum against MPTP-induced neurotoxicity were associated with inhibition of the neurotrophic signaling pathways and up-regulation of Nrf2 pathways. Thus, Cicadidae Periostracum mitigates neurotoxicity via neurotrophic signaling not only by increasing Nrf2 activity but also by increasing antioxidant activity. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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