| Autor: |
Kima López-Aldabe, Francesc Escrihuela-Vidal, Manel Tuells-Morales, Clàudia Llobera-Ris, Andrea Bauer-Alonso, Montserrat Cortes-Romera, Laura Gràcia-Sànchez, Marian Tormo-Ratera, Xavier Juanola Roura, Rosa Maria Penin-Mosquera, Xavier Corbella, Xavier Solanich |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
European Journal of Case Reports in Internal Medicine (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2284-2594 |
| DOI: |
10.12890/2022_003076 |
| Popis: |
Rosai-Dorfman-Destombes disease (RDD) or sinus histiocytosis with massive lymphadenopathy is a rare non-Langerhans cell histiocytosis of unknown cause. The disease often manifests as bilateral painless cervical lymphadenopathy associated with systemic symptoms such as fever and weight loss. Extranodal disease is also frequent and can involve any organ, mostly skin, nasal cavity, bone, and retro-orbital tissue. Swelling of cartilaginous tissues such as ear helix or laryngeal structures may mimic the entity known as relapsing polychondritis. Although spontaneous remission is the most expected evolution, some cases require systemic treatment with prednisone, methotrexate or cytotoxic agents, with variable success rates. In this respect, since somatic variants in genes involved in the mitogen-activated protein kinase (MAPK) pathway have been observed to play a pathogenic role in RDD, the use of therapies targeting these pathogenic variants seems to be a reasonable strategy. Here we present a case of RDD with extensive extranodal involvement that showed a rapid and complete response to the MEK inhibitor cobimetinib |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
