Prolonged response to first‐generation tyrosine kinase inhibitor in a metastatic non‐small cell lung cancer harbouring complex G719X and S768I mutations: A case report from Vietnam and literature review

Autor:	Kien Hung Do, Duc Thanh Le, Tai Van Nguyen, Tu Anh Do, Chu Van Nguyen
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	first‐generation TKIs G719X and S768I mutations NSCLC rare EGFR mutation Diseases of the respiratory system RC705-779
Zdroj:	Respirology Case Reports, Vol 11, Iss 5, Pp n/a-n/a (2023)
Druh dokumentu:	article
ISSN:	2051-3380
DOI:	10.1002/rcr2.1131
Popis:	Abstract A complex of G719X and S768I mutations is infrequently observed, constituting less than 0.3% of all EGFR‐positive non‐small cell lung cancer (NSCLC), and the response to first‐line TKIs is inconsistent in the literature. In this study, we report a patient with metastatic non‐small cell lung cancer carrying rare EGFR compound mutations of G719X and S768I who benefited from first‐line treatment with gefitinib in Vietnam. This patient had a prolonged response lasting over 44 months with first‐generation TKI. He continued to take gefitinib without experiencing serious adverse events. NSCLC with a rare complex of G719X and S768I mutation revealed a good response to gefitinib.
Databáze:	Directory of Open Access Journals
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