PERSONALIZED STATIN THERAPY IN IMPROVING THE TREATMENT OF CORONARY ARTERY DISEASE AND ATHEROSCLEROSIS

Autor:	U. R. Makhmudova, Sh. U. Hoshimov, G. J. Abdullayeva, A. B. Shek, R. D. Kurbanov
Jazyk:	ruština
Rok vydání:	2015
Předmět:	статины полиморфизмы генов метаболизма печени персонализированная фармакотерапия statins hepatic metabolism genes polymorphisms personalized pharmacotherapy Diseases of the circulatory (Cardiovascular) system RC666-701
Zdroj:	Евразийский Кардиологический Журнал, Vol 0, Iss 2, Pp 57-61 (2015)
Druh dokumentu:	article
ISSN:	2225-1685 2305-0748
DOI:	10.38109/2225-1685-2015-2-57-61
Popis:	This review examines the possibility of personalized pharmacotherapy with statins, based on the genotype of the individual patient. Identification of polymorphism of genes, responsible for the metabolism of the liver CYP3A5, CYP2C9 and transport of statins into the liver SLCO1B1, BCRP allows differentiated approach to their appointment and choice. This will not only increase the effectiveness of statins, but also to avoid serious side effects, primarily statin-induced myopathy and toxic hepatitis.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/55b448e7bcf34034bcf29714f243f3d8 Zobrazit plný text záznamu View record in DOAJ