| Autor: |
Yih Ru Wu, Louis C Tan, Xiaoli Fu, Chiung Mei Chen, Wing Lok Au, Ling Chen, Yi Chun Chen, Kumar M Prakash, Yifan Zheng, Guey-Jen Lee-Chen, Yi Zhao, Jin-Sheng Zeng, Eng King Tan, Zhong Pei |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
PLoS ONE, Vol 7, Iss 7, p e36123 (2012) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0036123 |
| Popis: |
It has been suggested that a common LRRK2 polymorphic variant (A419V (rs34594498 C >T)) may be a risk factor among Asians (especially in Taiwan). In this study, we examined this variant in a larger and independent Taiwan cohort. We found the frequency of the variant (A419V) to be very rare in our Taiwan PD and controls (?0.6%). Further studies were conducted in two other Chinese populations (Singapore and China), comprising of a total of 3004 subjects including 1517 PD patients and 1487 control subjects. However, our multi-center Chinese study revealed that the frequency of the variant was rare (?0.4%) and was not associated with risk of PD, suggesting that the variant is not a major risk factor for PD among Chinese, at least in our study population. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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