Increase in Kelch 13 Polymorphisms in Plasmodium falciparum, Southern Rwanda

Autor:	Clara Bergmann, Welmoed van Loon, Felix Habarugira, Costanza Tacoli, Julia C. Jäger, Darius Savelsberg, Fabian Nshimiyimana, Elias Rwamugema, Djibril Mbarushimana, Jules Ndoli, Augustin Sendegeya, Claude Bayingana, Frank P. Mockenhaupt
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	antimicrobial resistance artemisinin Kelch malaria mutation parasites Medicine Infectious and parasitic diseases RC109-216
Zdroj:	Emerging Infectious Diseases, Vol 27, Iss 1, Pp 294-296 (2021)
Druh dokumentu:	article
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid2701.203527
Popis:	Artemisinin resistance in Plasmodium falciparum is associated with nonsynonymous mutations in the Kelch 13 (K13) propeller domain. We found that 12.1% (8/66) of clinical P. falciparum isolates from Huye district, Rwanda, exhibited K13 mutations, including R561H, a validated resistance marker. K13 mutations appear to be increasing in this region.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/55a992f6df884c09b25090cfbcf98b09 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF