Autoimmune hemolytic anemia: the current state of the issue

Autor:	P. I. Vasilchenkova, I. V. Galtseva, E. A. Lukina
Jazyk:	ruština
Rok vydání:	2023
Předmět:	autoimmune hemolytic anemia cold agglutinin disease autoantibodies hemolysis t-helpers t-killers regulatory t-cells flow cytometry rituximab Diseases of the blood and blood-forming organs RC633-647.5
Zdroj:	Онкогематология, Vol 18, Iss 2 (2023)
Druh dokumentu:	article
ISSN:	1818-8346 2413-4023
DOI:	10.17650/1818-8346-2023-18-2-60-67
Popis:	Autoimmune hemolytic anemia is a rare disease characterized by the appearance of anti-erythrocyte autoantibodies and subsequent destruction of red blood cells by cells of the immune system. The destruction mechanisms of erythrocytes loaded with autoantibodies are well studied; however, the initial mechanisms that trigger the production of antibodies to own erythrocytes antigens remain unclear. In the pathogenesis of autoimmune hemolytic anemia, an important role is played by impaired immunological tolerance, in which T-lymphocytes play a key role. The study of T-lymphocytes subpopulation in patients with autoimmune hemolytic anemia by flow cytometry can provide valuable information for studying the disease pathogenesis and developing new approaches to its treatment.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/5598b022203845c49fc24422493fc490 Zobrazit plný text záznamu View record in DOAJ