Phytochemical Screening and Anti-Inflammatory Effect of Marrubium vulgare L. Methanol Extract on Carrageenan- Induced Paw Inflammation in Rats

Autor: Fatemeh Fathiazad, Maryam Rameshrad, Samira Asghari, Sanaz Hamedeyazdan, Alireza Garjani, Nasrin Maleki-Dizaji
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Pharmaceutical Sciences, Vol 23, Iss 1, Pp 3-11 (2017)
Druh dokumentu: article
ISSN: 2383-2886
DOI: 10.15171/PS.2017.02
Popis: Background: The upward desire in using traditional medicine as a remedy for treatment of different diseases has led the scientists to be thoughtful on plants as alternative sources of conventional drugs. Methods: Herein, anti-inflammatory effects of Marrubium vulgare methanolic extract was evaluated in carrageenan- induced paw edema in rats through examining paw thickness, histological studies and myeloperoxidase activity (MPO). The antioxidant activity of M. vulgare extract and its phenolic and flavonoids content were evaluated by folin-Ciocalteau, and aluminum chloride colorimetric assay, separately. Results: The results showed that M. vulgare alleviated paw inflammation as indexed by reduction paw thickness (p
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