Molecular residual disease: A new clue for individualized approach in non‐small cell lung cancer

Autor:	Jia‐Tao Zhang, Wen‐Zhao Zhong, Yi‐Long Wu
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	ctDNA individualized therapy molecular residual disease non‐small cell lung cancer Medicine
Zdroj:	Medicine Advances, Vol 1, Iss 1, Pp 79-88 (2023)
Druh dokumentu:	article
ISSN:	2834-4405 2834-4391
DOI:	10.1002/med4.11
Popis:	Abstract The prognostic value of molecular residual disease (MRD) in non‐small cell lung cancer (NSCLC) cases using high‐depth circulating tumor DNA (ctDNA) sequencing has been well documented. The utility of MRD to direct individualized therapy has increasingly emerged in the clinical trial design of solid tumors, such as escalation or de‐escalation of adjuvant therapy based on MRD. And the efficiency of MRD assay is a key determinant to the success of clinical trials, especially the limitation of detection and predictive value. Here, we review the progress made in evaluating the clinical validity of ctDNA‐MRD test and provide insight into exploiting these developments to future clinical scenarios for improving the individualized therapy of NSCLC.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/ea554e23797148f0bf394ecb8dc1c85e Zobrazit plný text záznamu Plný text View record in DOAJ