Labor epidural analgesia and risk of autism Spectrum disorders in offspring: A systematic review and meta-analysis

Autor: Ling-ling Fang, Yuan-yue Zhou, Hai-yin Jiang, Yu-dan Shi
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Frontiers in Pediatrics, Vol 10 (2023)
Druh dokumentu: article
ISSN: 2296-2360
DOI: 10.3389/fped.2022.965205
Popis: BackgroundThe effect of labor epidural anesthesia (LEA) on the risk of autism spectrum disorder (ASD) in offspring has been investigated recently, and available results are inconsistent.MethodsWe searched the PubMed and EMBASE databases for relevant studies and performed a systematic review and meta-analysis of the literature. Subgroup analyses were conducted to assess the sources of heterogeneity. Both fixed and random effects models were used was used to estimate overall relative risk.ResultsOur results showed that LEA was associated with an increased risk of ASD in offspring [HR = 1.3, 95% confidence interval (CI): 1.25–1.35; P
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