On the interchangeability of calcineurine inhibitors

Autor:	K. E. Zatolochina, R. N. Alyautdin, E. O. Zhuravleva, E. Yu. Pasternak, M. A. Darmostukova, E. Yu. Kolesnikova, B. K. Romanov
Jazyk:	ruština
Rok vydání:	2018
Předmět:	ингибиторы кальциневрина циклоспорин такролимус биоэквивалентность взаимозаменяемость calcineurine inhibitors cyclosporine tacrolimus bioequivalence interchangeability Therapeutics. Pharmacology RM1-950
Zdroj:	Безопасность и риск фармакотерапии, Vol 0, Iss 2, Pp 5-10 (2018)
Druh dokumentu:	article
ISSN:	2312-7821 2619-1164
Popis:	Calcineurin inhibitors, cyclosporine and tacrolimus, are the main immunosuppressants used in solid organ transplantation, but the peculiarities of their pharmacokinetics allow to classify them to a group of medicines with a narrow therapeutic range. Currently in Russia more than 10 generic drugs of cyclosporine and tacrolimus are used. In this review the problem of interchangeability of cyclosporine and tacrolimus is discussed. The pharmacokinetic and technological factors that affect the bioequivalence of calcineurin inhibitors are presented.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/5530f2035b564d63ab942c4f4257a11f Zobrazit plný text záznamu View record in DOAJ