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Resumen: La enfermedad de Parkinson (EP) es una enfermedad neurodegenerativa cuyo tratamiento sintomático más eficaz es la L-dopa, sin embargo, puede inducir discinesias (DIL). La Mucuna pruriens (Mp) ha demostrado propiedades efectivas para el tratamiento de la EP reduciendo la DIL. Se comprobó la disminución de las discinesias en un modelo de Parkinson y discinesia en ratas Wistar tratadas con Mp. Se manipularon 28 machos, distribuidos en 4 grupos: Control, DIL, L-MP1 (Mp 75 mg/kg) y L-MP2 (Mp 150 mg/kg). La EP se indujo con 6-hidroxidopamina y la discinesia se provocó mediante inyección de L-Dopa y benserazida.Se analizaron 4 tipos de movimientos involuntarios anormales (MIA); axial, miembro anterior, orolingual y locomotor, que disminuyeron significativamente en los grupos tratados con Mp: discinesia axial L-Mp1 x = 0,05 y DIL x = 1,60; miembro anterior L-Mp1 x = 1,28 y DIL x = 2,06; orolingual L-Mp1 x = 0,18 y DIL x = 1,34; locomotor L-Mp1 x = 0,17 y DIL x = 1,17. Se puede concluir que la Mp disminuye la frecuencia de las discinesias dependiendo de la topografía y dosis administrada. Abstract: Parkinson's disease (PD) is a neurodegenerative disease for which the most effective symptomatic treatment is levodopa; however, the drug can induce dyskinesia (levodopa-induce dyskinesia; LID). Mucuna pruriens (Mp) has shown to be effective for the treatment of PD by reducing the rate of LID. We tested this reduction in dyskinesia in a model of PD and dyskinesia in Wistar rats treated with Mp. We manipulated 28 male animals, distributed in 4 groups: control, LID, L-MP1 (Mp at 75 mg/kg), and L-MP2 (Mp at 150 mg/kg). PD was induced with 6-hydroxydopamine, and dyskinesia was induced with injection of levodopa and benserazide. We analysed 4 types of abnormal involuntary movements: axial, forelimb, orolingual, and locomotor. All 4 types of movements decreased significantly in the groups treated with Mp: axial dyskinesia (L-Mp1, x = 0.05, vs LID, x = 1.60); forelimb (L-Mp1, x = 1.28, vs LID, x = 2.06); orolingual (L-Mp1, x = 0.18, vs LID, x = 1.34); locomotor (L-Mp1, x = 0.17, vs LID, x = 1.17). We may conclude that Mp reduces the frequency of dyskinesia depending on the topography dose administered. |
