Generation of patient-specific induced pluripotent stem cells (ZZUSAHi001-A) derived from a familial atrial fibrillation patient carrying KCNA5 c.775G>A mutation

Autor: Shaohui Niu, Haiyan Xiong, Yuan Li, Lihua Zhang
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Stem Cell Research, Vol 47, Iss , Pp 101915- (2020)
Druh dokumentu: article
ISSN: 1873-5061
DOI: 10.1016/j.scr.2020.101915
Popis: Peripheral blood mononuclear cells (PBMCs) were isolated from a 57-year-old female who was clinically diagnosed as familial atrial fibrillation and were reprogrammed using non-integrative Sendai viral vectors containing reprogramming factors OCT4, SOX2, KLF4 and cMYC. The generated human induced pluripotent stem cell (hiPSC) line, ZZUSAHi001-A, exhibited a normal karyotype, showed robust expression of pluripotency markers and differentiated towards three germ layers in vivo.
Databáze: Directory of Open Access Journals