Mild Albuminuria Is a Risk Factor for Faster GFR Decline in the Nondiabetic Population

Autor: Toralf Melsom, Marit Dahl Solbu, Jørgen Schei, Vidar Tor Nyborg Stefansson, Jon Viljar Norvik, Trond Geir Jenssen, Tom Wilsgaard, Bjørn Odvar Eriksen
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Kidney International Reports, Vol 3, Iss 4, Pp 817-824 (2018)
Druh dokumentu: article
ISSN: 2468-0249
DOI: 10.1016/j.ekir.2018.01.015
Popis: Introduction: A minimal increase in the albumin-to-creatinine ratio (ACR) predicts cardiovascular disease and mortality, but whether it predicts kidney function loss in nondiabetic persons is unclear. We investigated the association between ACR in the optimal or high-normal range and the rate of glomerular filtration rate (GFR) decline in a cohort from the general population without diabetes, cardiovascular, or chronic kidney disease. Methods: In the Renal Iohexol Clearance Survey, we measured GFR using iohexol clearance in 1567 middle-aged nondiabetic individuals with an ACR
Databáze: Directory of Open Access Journals