Protective effect of zinc supplementation on renal ischemia/reperfusion injury in rat: Gender-related difference
| Autor: | Fatemeh Moslemi, Ardeshir Talebi, Mehdi Nematbakhsh |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | International Journal of Preventive Medicine, Vol 10, Iss 1, Pp 68-68 (2019) |
| Druh dokumentu: | article |
| ISSN: | 2008-7802 2008-8213 |
| DOI: | 10.4103/ijpvm.IJPVM_279_17 |
| Popis: | Background: Zinc (Zn) knows as essential microelement which prevents oxidative stress. The effect of Zn supplement on renal function parameters in rats subjected to renal ischemia-reperfusion (IR) injury was investigated. Methods: Male and female rats were subjected to renal IR with and without Zn sulfate (10 mg/kg/day for 5 days) supplementation. The kidney function markers and histology findings in Zn-treated group were compared with sham and control groups. Results: The serum levels of blood urea nitrogen and creatinine (Cr) and kidney tissue damage score were increased significantly after renal injury (P < 0.05) gender dependently, but no alterations were observed for these markers in Zn-treated animals after renal IR injury. Cr clearance was significantly different between genders (P < 0.05); however, Zn supplementation increased the Cr clearance and kidney nitrite level significantly in male rats (P < 0.05). Zn also increased urine flow in female (P < 0.05), but it did not alter urine load of Na (UNaV) and percentage of Na excretion (ENa%). Conclusions: Zn may improve renal function after IR injury gender dependently. |
| Databáze: | Directory of Open Access Journals |
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