| Autor: |
Juan C. Uzquiano, Ana Alonso Méndez, Álvaro Juano Bielsa, María Dolores García-Cosío Carmena, Juan F. Delgado Jiménez, Paz Sanz-Ayán |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Transplantation Reports, Vol 7, Iss 3, Pp 100103- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2451-9596 |
| DOI: |
10.1016/j.tpr.2022.100103 |
| Popis: |
Background: Osteoporosis is a prevalent complication in heart transplant population. Denosumab is a monoclonal antibody that inhibits bone resorption approved for the treatment of corticosteroid-induced osteoporosis and potentially useful in heart transplant recipients. Objective: To describe the metabolic and densitometric effects of denosumab in these patients, as well as the adverse effects observed. Methods: We performed a study of 9 transplant patients between 2014 and 2019 who were treated with denosumab for osteopenia or osteoporosis. All patients received postoperative calcium and vitamin D supplements. We measured the changes in densitometric and metabolic variables and compared them by Student's t-test. Results: After therapy, bone mineral density (BMD) and Tscore at lumbar spine improved a mean of 0.0458 and 0.5000, respectively (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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