| Autor: |
Javier Martín-Escolano, Sonsoles Salto-Alejandre, Carmen Infante-Domínguez, Marta Carretero-Ledesma, Natalia Maldonado-Lizarazo, Pedro Camacho-Martínez, Francisco Martín-Domínguez, Inmaculada Tallón-Ruiz, Ana Ruiz-Molina, Zaira Palacios-Baena, Patricia Pérez-Palacios, María Paniagua-García, Rocío Álvarez-Marín, Laura Merino, José Miguel Cisneros, Elisa Cordero, Jerónimo Pachón, José Antonio Pérez-Simón, Javier Sánchez-Céspedes, Manuela Aguilar-Guisado |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
International Journal of Infectious Diseases, Vol 146, Iss , Pp 107163- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1201-9712 |
| DOI: |
10.1016/j.ijid.2024.107163 |
| Popis: |
Objectives: Patients with haematologic malignancies (HM) COVID-19 have more severe disease, with increased risk of mortality. Therefore, this study aimed to evaluate the effect of SARS-CoV-2 RNAemia and the specific humoral immune responses on the clinical outcomes of patients with HM and COVID-19. Methods: Interferon-α/γ (IFN-α/IFN-γ) serum levels, neutralizing antibodies and RNAemia at COVID-19 diagnosis, and persistent RNAemia during the follow-up were evaluated. Results: Overall, 63 (58.9%) out of 107 patients had RNAemia, which was persistent in 26 (41.3%) patients. RNAemia at diagnosis and persistent RNAemia were associated with the need for high-flow nasal oxygen therapy during admission. Persistent RNAemia, age >70 years, and CURB-65 score ≥2 in patients with pneumonia were associated with increased 90-day mortality (P = 0.009, P = 0.030 and P = 0.001, respectively). The 90-day overall survival was lower (P = 0.006) in patients with persistent RNAemia. In addition, dexamethasone administration was associated with a COVID-19 episode with persistent RNAemia. Conclusion: Our results suggest that in patients with HM, RNAemia at the time of COVID-19 diagnosis and during the follow-up can be used to stratify patients with HM according to their clinical evolution and to guide clinical decisions tailored to the specific needs of each patient. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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