Comparative effects of balm hydro alcoholic extract and diazepam on reducing anxiety of in mice
| Autor: | M Modaresi, M Basravi, I Sajadia |
|---|---|
| Jazyk: | perština |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Armaghane Danesh Bimonthly Journal, Vol 20, Iss 10, Pp 848-857 (2016) |
| Druh dokumentu: | article |
| ISSN: | 1728-6506 1728-6514 |
| Popis: | Background & aim: Anxiety is a normal feeling which is experienced in threatening situations and can affect neural system. Wide spread of anxiety forces many people to permanent use of anti-stress drugs especially benzodiazepines. This study was carried out to compare the effects of balm extract and diazepam on anxiety adjustment. Methods: In this experimental study 70 female mice weighing approximately 25 to 30 g were studied in seven treatments groups including control, placebo, anxiety, diazepam, 50, 100, and 200 mg/kg of balm’s hydro-alcoholic extract. Drug and extract doses were injected IP. After receiving the last dose, anxiety was induced using dark box and was evaluated by an elevated plus-maze. In order to increase the activity, the animals were kept in a box with black walls for 5 minutes. Then, in order to evaluate the response of anxiety in elevated plus maze transferred and count the time spent in the open arms for 5 minutes (as an indicator of anxiety) were observed and recorded. Obtained data were analyzed using SPSS 11.5 software. Results: The results of tests on the treatment showed that the hydro alcoholic extract in 200 mg/kg dose increased the time of presence in open arms significantly which shows anxiety reduction. Also, movement activities of mice were significantly higher in this dose in proportion to diazepam. Conclusion: According to results, hydro alcoholic extract of balm in 200 mg/kg dose can be a suitable replacement for diazepam in reducing anxiety reflexes. |
| Databáze: | Directory of Open Access Journals |
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