Identification of somatic mutations in single cell DNA-seq using a spatial model of allelic imbalance

Autor: Lovelace J. Luquette, Craig L. Bohrson, Max A. Sherman, Peter J. Park
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-019-11857-8
Popis: Single cell whole-genome sequencing data harbors information about somatic genetic variation but is challenging to analyze. Here, the authors develop a spatial model to correct for allelic amplification imbalance and a somatic SNV genotyper SCAN-SNV for analyzing single cell DNA sequencing data.
Databáze: Directory of Open Access Journals