Oxidative Distress in Patients with Polytrauma
| Autor: | M. Sh. Khubutia, A. K. Shabanov, G. V. Bulava, A. G. Dorfman, Z. M. Zainudinov, M. V. Skulachev, A. N. Kuzovlev, O. A. Grebenchikov, A. A. Sergeev, M. I. Shpitonkov, G. Yu. Maltsev |
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| Jazyk: | English<br />Russian |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Общая реаниматология, Vol 10, Iss 2, Pp 23-30 (2014) |
| Druh dokumentu: | article |
| ISSN: | 1813-9779 2411-7110 |
| DOI: | 10.15360/1813-9779-2014-2-23-30 |
| Popis: | Polytrauma is a serious threat to human life not only due to its direct damage to vital organs, but also to the development of significant oxidative distress that gives rise to multiple organ dysfunction. At the same time, the risk of lifethreatening infectious complications increases.Objective: to study oxidative distress over time and its association with early pulmonary infectious complications in patients with polytrauma.Subjects and methods. The authors examined 35 patients with polytrauma in the first 6—12 and 12—24 hours and 3, 5—7, and 10 days after injury and 25 healthy volunteers. Having regard to the development of pulmonary infectious complications, they formed two comparison groups of patients: 1) 15 patients without pneumonia and 2) 20 patients with pneumonia. The investigation used the antioxidant index (AOI) considering the activity of erythrocyte enzymes (superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase) and the degree of lipid peroxidation in the plasma (dienic conjugates and malonic dialdehyde) to estimate the balance between oxidative lesions and the performance of the body's antioxidant systems.Results. In both groups, the AOI reflects the oxidative stress state, as substantiated by negative values for the AOI with its normal value equal to zero. However, with the virtually parallel nature of AOI changes after injury in the patients with pneumonia, the values of the index were significantly lower than in those without complications within the first 6—12 and 12—24 hours and 5—7 days (p |
| Databáze: | Directory of Open Access Journals |
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