Effect of XBB.1.5-adapted booster vaccination on the imprinting of SARS-CoV-2 immunity

Autor:	Jernej Pušnik, Werner O. Monzon-Posadas, Emmanuil Osypchuk, Aleksandra Elzbieta Dubiel, Maximilian Baum, Paulina Fehring, Antonia Büning, Tobias Klant, Hendrik Streeck
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	npj Vaccines, Vol 9, Iss 1, Pp 1-5 (2024)
Druh dokumentu:	article
ISSN:	2059-0105
DOI:	10.1038/s41541-024-01023-7
Popis:	Abstract In the present study, Pušnik et al. investigated whether the XBB.1.5-adapted booster can overcome the persistent imprinting of SARS-CoV-2 immunity by wild-type based vaccines. The findings demonstrate increased plasma neutralization against the homologous variant following the booster vaccination. Formation of de novo humoral response against the mutated epitopes of XBB.1.5 variant’s surface proteins was observed in 3/20 individuals. The booster vaccination had no significant effect on T-cell response.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/54f3e1c6f8fb45c298f89db863e4a5b8 Zobrazit plný text záznamu Full text from SpringerLink View record in DOAJ