Spinal diffuse midline glioma: An unusual case presentation
| Autor: | Nadia Beringer, Kate G. Bennett, Despina Demopoulos, Marelize Reynders, Linda Doedens, Felicia Tshite, Deborah Pearce, Raazik Gani, Dawn-Lee van der Byl, Duvern Ramiah, Pieter E. Boshoff, Christos Profyris, John Ouma, Abhijit Joshi, Simon Bailey |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | South African Journal of Oncology, Vol 8, Iss 0, Pp e1-e6 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2518-8704 2523-0646 |
| DOI: | 10.4102/sajo.v8i0.306 |
| Popis: | Primary spinal cord neoplasms are rare, accounting for 1% of paediatric central nervous system tumours. The majority of which are low-grade gliomas (LGG). A teenage male presented with rapidly progressive lower limb paralysis. He subsequently underwent a near-total resection of an intramedullary thoracic tumour. Although the initial histopathology report suggested a LGG, closer review of the morphology and immunohistochemical staining revealed a diffusely infiltrating high-grade astrocytoma. Methylation profiling later confirmed a H3K27M-mutated spinal DMG. He underwent spinal radiation to the tumour bed soon after surgery but succumbed to his disease 8 days after completing radiation, and 3 months after presentation. Conclusion: Spinal DMGs are rare, can lead to diagnostic challenges and have a poor prognosis. |
| Databáze: | Directory of Open Access Journals |
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