| Autor: |
Philip Chiu-Tsun Tang, Ying-Ying Zhang, Jane Siu-Fan Li, Max Kam-Kwan Chan, Jiaoyi Chen, Ying Tang, Yiming Zhou, Dongmei Zhang, Kam-Tong Leung, Ka-Fai To, Sydney Chi-Wai Tang, Hui-Yao Lan, Patrick Ming-Kuen Tang |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Non-Coding RNA, Vol 8, Iss 3, p 36 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2311-553X |
| DOI: |
10.3390/ncrna8030036 |
| Popis: |
Transforming growth factor-β (TGF-β) is a crucial pathogenic mediator of inflammatory diseases. In tissue fibrosis, TGF-β regulates the pathogenic activity of infiltrated immunocytes and promotes extracellular matrix production via de novo myofibroblast generation and kidney cell activation. In cancer, TGF-β promotes cancer invasion and metastasis by enhancing the stemness and epithelial mesenchymal transition of cancer cells. However, TGF-β is highly pleiotropic in both tissue fibrosis and cancers, and thus, direct targeting of TGF-β may also block its protective anti-inflammatory and tumor-suppressive effects, resulting in undesirable outcomes. Increasing evidence suggests the involvement of long non-coding RNAs (lncRNAs) in TGF-β-driven tissue fibrosis and cancer progression with a high cell-type and disease specificity, serving as an ideal target for therapeutic development. In this review, the mechanism and translational potential of TGF-β-associated lncRNAs in tissue fibrosis and cancer will be discussed. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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