It Takes Two to Tango: Controlling Human Mesenchymal Stromal Cell Response via Substrate Stiffness and Surface Topography

Autor:	Sofia Ribeiro, Alexandre Watigny, Yves Bayon, Manus Biggs, Dimitrios I. Zeugolis
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	differentiation human mesenchymal stromal cells mechanotransduction stiffness topography Biotechnology TP248.13-248.65 Medical technology R855-855.5
Zdroj:	Advanced NanoBiomed Research, Vol 4, Iss 1, Pp n/a-n/a (2024)
Druh dokumentu:	article
ISSN:	2699-9307
DOI:	10.1002/anbr.202300042
Popis:	Cells sense extracellular matrix‐induced biophysical signals, which are transduced into intracellular signaling cascades, and trigger a series of cell responses, including adhesion, migration, and lineage commitment. Traditionally, in in vitro context, monofactorial approaches are employed to control cell fate, despite the fact that in vivo cells are exposed simultaneously to a diverse range of signals. Herein, an overview of key mechanotransduction pathways is first provided. Conventional single‐factor and contemporary multifactorial methodologies, based on substrate rigidity and surface topography, are then reviewed to recapitulate in vitro the in vivo niche, in an attempt to elucidate the underlying mechanisms involved in human mesenchymal stromal cell‐material interactions.
Databáze:	Directory of Open Access Journals
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