Association of breast cancer grade with response to neoadjuvant chemotherapy assessed postoperatively
| Autor: | Michał Jarząb, Ewa Stobiecka, Agnieszka Badora-Rybicka, Ewa Chmielik, Małgorzata Kowalska, Wiesław Bal, Anna Polakiewicz-Gilowska, Barbara Bobek-Billewicz, Dariusz Lange, Rafał Tarnawski |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Polish Journal of Pathology, Vol 70, Iss 2, Pp 91-99 (2019) |
| Druh dokumentu: | article |
| ISSN: | 1233-9687 2084-9869 |
| DOI: | 10.5114/pjp.2019.87101 |
| Popis: | Currently, breast cancer chemotherapy response can be predicted based on various parameters, with common reporting of tumour grade and Ki67 proliferation index. We analysed their association with pathological complete response (pCR) in a multivariate approach. The study was carried out in a group of 353 patients, treated by preoperative chemotherapy and prospectively observed. In selected patients, parallel to routing core needle biopsy assessment, gene expression profile of tumour was analysed by oligonucleotide microarrays. Tumour parameters associated with pCR in univariate analysis were: tumour grade, nuclear grade, mitotic index, Ki67, oestrogen and progesterone receptor (all p |
| Databáze: | Directory of Open Access Journals |
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