| Autor: |
Tohru Daikoku, Yoshihiro Yoshida, Tomoko Okuda, Kimiyasu Shiraki |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
Journal of Pharmacological Sciences, Vol 126, Iss 3, Pp 281-284 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
1347-8613 |
| DOI: |
10.1254/jphs.14156SC |
| Popis: |
Abstract.: T-705 (favipiravir) is a potent inhibitor of RNA polymerases of influenza viruses. Susceptibility variants were isolated during passages in the presence of T-705. Nine variants with 0.4 to 2.1 times the 50% inhibitory concentration for plaque formation of the parent A/PR/8/34 (H1N1) strain had amino acid variations in the PB1, PB2, and PA genes of the RNA polymerase complex. However, the variation patterns in the RNA polymerase complex indicated that T-705 does not work as a mutagen, and resistant mutants were not isolated, possibly because a mutation leading to resistance would be lethal to the RNA polymerase function. Keywords:: influenza virus, T-705, favipiravir |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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