| Autor: |
Marco Napoli, Xiaobo Li, Hayley D. Ackerman, Avani A. Deshpande, Ivan Barannikov, Marlese A. Pisegna, Isabelle Bedrosian, Jürgen Mitsch, Philip Quinlan, Alastair Thompson, Kimal Rajapakshe, Cristian Coarfa, Preethi H. Gunaratne, Douglas C. Marchion, Anthony M. Magliocco, Kenneth Y. Tsai, Elsa R. Flores |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-020-18973-w |
| Popis: |
Mutations in TP53 and hyperactivation of the PI3K/AKT pathway are the two most frequent drivers of cancer progression across multiple human tumour types. Here, the authors identify two TAp63 regulated long non-coding RNAs, TROLL-2 and TROLL-3, that connect these oncogenic pathways, thus promoting tumour and metastasis formation in a wide variety of cancer types. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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