| Autor: |
Urszula Brykczynska, Marco Geigges, Sophia J. Wiedemann, Erez Dror, Marianne Böni-Schnetzler, Christoph Hess, Marc Y. Donath, Renato Paro |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Cell Reports, Vol 30, Iss 5, Pp 1627-1643.e7 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2211-1247 |
| DOI: |
10.1016/j.celrep.2020.01.005 |
| Popis: |
Summary: The innate immune system safeguards the organism from both pathogenic and environmental stressors. Also, physiologic levels of nutrients affect organismal and intra-cellular metabolism and challenge the immune system. In the long term, over-nutrition leads to low-grade systemic inflammation. Here, we investigate tissue-resident components of the innate immune system (macrophages) and their response to short- and long-term nutritional challenges. We analyze the transcriptomes of six tissue-resident macrophage populations upon acute feeding and identify adipose tissue macrophages and the IL-1 pathway as early sensors of metabolic changes. Furthermore, by comparing functional responses between macrophage subtypes, we propose a regulatory, anti-inflammatory role of heat shock proteins of the HSP70 family in response to long- and short-term metabolic challenges. Our data provide a resource for assessing the impact of nutrition and over-nutrition on the spectrum of macrophages across tissues with a potential for identification of systemic responses. : Brykczynska et al. investigate the response of tissue-resident macrophages to short- and long-term nutritional challenges. They identify adipose tissue macrophages and the IL-1 pathway as early sensors of metabolic changes and propose a regulatory role for heat shock proteins in response to acute and chronic metabolic perturbances. Keywords: macrophages, obesity, diabetes, high fat diet, postprandial, IL-1, HSP |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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