Identifying critical age and gender-based metabolomic shifts in a Japanese population of the Tohoku Medical Megabank cohort
| Autor: | Miyuki Sakurai, Ikuko N. Motoike, Eiji Hishinuma, Yuichi Aoki, Shu Tadaka, Mana Kogure, Masatsugu Orui, Mami Ishikuro, Taku Obara, Naoki Nakaya, Kazuki Kumada, Atsushi Hozawa, Shinichi Kuriyama, Masayuki Yamamoto, Seizo Koshiba, Kengo Kinoshita |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2045-2322 37164546 |
| DOI: | 10.1038/s41598-024-66180-0 |
| Popis: | Abstract Understanding the physiological changes associated with aging and the associated disease risks is essential to establish biomarkers as indicators of biological aging. This study used the NMR-measured plasma metabolome to calculate age-specific metabolite indices. In doing so, the scope of the study was deliberately simplified to capture general trends and insights into age-related changes in metabolic patterns. In addition, changes in metabolite concentrations with age were examined in detail, with the period from 55–59 to 60–64 years being a period of significant metabolic change, particularly in men, and from 45–49 to 50–54 years in females. These results illustrate the different variations in metabolite concentrations by sex and provide new insights into the relationship between age and metabolic diseases. |
| Databáze: | Directory of Open Access Journals |
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