Clinicopathological characteristics, survival outcomes, and genetic alterations of younger patients with gastric cancer: Results from the China National Cancer Center and cBioPortal datasets

Autor:	Penghui Niu, Huang Huang, Lulu Zhao, Tongbo Wang, Xiaojie Zhang, Wanqing Wang, Yawei Zhang, Chunguang Guo, Dongbing Zhao, Yingtai Chen
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	clinicopathological characteristics gastric cancer genetic alterations survival outcomes younger patient Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Cancer Medicine, Vol 11, Iss 16, Pp 3057-3073 (2022)
Druh dokumentu:	article
ISSN:	2045-7634
DOI:	10.1002/cam4.4669
Popis:	Abstract Background The survival outcomes of younger patients with gastric cancer (GC) have remained controversial. This study explores the clinicopathological characteristics, survival outcomes, and genetic alterations of younger and older patients with GC. Methods Patients with GC were identified from the China National Cancer Center Gastric Cancer Database (NCCGCDB) during 1998–2018. Survival analysis was conducted using Kaplan–Meier estimates and Cox proportional hazards models. Sequencing datasets were enrolled from The Cancer Genome Atlas (TCGA) and Memorial Sloan–Kettering Cancer Center (MSKCC) databases. Results A total of 1146 younger (
Databáze:	Directory of Open Access Journals
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