| Popis: |
M Bajc,1 Y Chen,2 J Wang,3 XY Li,4 WM Shen,4 CZ Wang,3 H Huang,2 A Lindqvist,5 XY He6 1Department of Clinical Science Physiology and Nuclear Medicine, Skåne University Hospital, Lund, Sweden; 2Respiratory Department, Changzheng Hospital, Shanghai, 3Respiratory Department, Xinqiao Hospital, Chongqing, 4Respiratory Department, Huadong Hospital, Shanghai, China; 5Department of Pulmonary Medicine, Heart and Lung Center, Helsinki University Hospital and Helsinki University, Helsinki, Finland; 6Suzhou University Affiliated Tumor Hospital, Wuxi, China Introduction: Airway obstruction and possible concomitant pulmonary diseases in COPD cannot be identified conventionally with any single diagnostic tool. We aimed to diagnose and grade COPD severity and identify pulmonary comorbidities associated with COPD with ventilation/perfusion single-photon emission computed tomography (V/P SPECT) using Technegas as the functional ventilation imaging agent.Methods: 94 COPD patients (aged 43–86 years, Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages I–IV) were examined with V/P SPECT and spirometry. Ventilation and perfusion defects were analyzed blindly according to the European guidelines. Penetration grade of Technegas in V SPECT measured the degree of obstructive small airways disease. Total preserved lung function and penetration grade of Technegas in V SPECT were assessed by V/P SPECT and compared to GOLD stages and spirometry.Results: Signs of small airway obstruction in the ventilation SPECT images were found in 92 patients. Emphysema was identified in 81 patients. Two patients had no signs of COPD, but both of them had a pulmonary embolism, and in one of them we also suspected a lung tumor. The penetration grade of Technegas in V SPECT and total preserved lung function correlated significantly to GOLD stages (r=0.63 and −0.60, respectively, P |
