| Autor: |
Ke Zhu, Yumei Lai, Huiling Cao, Xiaochun Bai, Chuanju Liu, Qinnan Yan, Liting Ma, Di Chen, Giedrius Kanaporis, Junqi Wang, Luyuan Li, Tao Cheng, Yong Wang, Chuanyue Wu, Guozhi Xiao |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-019-14186-y |
| Popis: |
Beta cell dysfunction and reduction in beta cell mass are hallmark events in the pathogenesis of diabetes mellitus. We identify focal adhesion protein Kindlin-2 as a key factor that controls insulin synthesis and secretion and beta cell mass by modulating MafA and beta-catenin proteins in pancreatic beta cells. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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