| Autor: |
MA Yao, JIANG Zhaowei, JIN Yunyi, MIAO Qian, ZHANG Chunxiang, ZHANG Linkun |
| Jazyk: |
čínština |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
口腔疾病防治, Vol 27, Iss 11, Pp 695-702 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2096-1456 |
| DOI: |
10.12016/j.issn.2096-1456.2019.11.003 |
| Popis: |
Objective To investigate the expression and function of the TNF signaling pathway in the early stage of orthodontic tooth movement with periodontitis and to provide evidence to study the early inflammatory response in patients with periodontitis orthodontic treatment. Methods Sixteen SD rats were randomly divided into four groups: group A--12 h of orthodontic tooth movement of the bilateral maxillary first molars in rats with periodontitis; group B--periodontitis model of the bilateral maxillary first molars without orthodontic tooth movement; group C--12 h of orthodontic tooth movement of the same teeth in rats with healthy periodontium; group D--control group without operations. The bilateral maxillary first molars and surrounding periodontal tissue of each group were collected for gene chip detection. Pathway enrichment analysis, qRT-PCR and GO (gene ontology) analysis were performed to identify differential genes involved in the TNF signaling pathway. Results Gene chip results showed that the TNF signaling pathway was significantly upregulated in group A, group B and group C (P group B > group C (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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