Association between serum CA125 levels in preeclampsia and its severity among women in Lagos, South-West Nigeria

Autor: Gbemisola E. Osanyin, Kehinde S. Okunade, Ayodeji Ayotunde Oluwole
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Hypertension in Pregnancy, Vol 37, Iss 2, Pp 93-97 (2018)
Druh dokumentu: article
ISSN: 1064-1955
1525-6065
10641955
DOI: 10.1080/10641955.2018.1460667
Popis: Background: Preeclampsia is a syndrome of unknown etiology characterized by hypertension, proteinuria, and/or organ dysfunction. CA125 is an antigenic determinant recognized by the murine monoclonal antibody OC125 quantified by radioimmunoassay. Its role in obstetrics is yet to be fully understood as most clinical trials advocating its uses are widely experimental in nature and unacknowledged. Aim: This study was done to assess the relationship between serum concentration of CA125 in normal pregnancies and those complicated with preeclampsia. Methods: A case–control study involving 70 women diagnosed with preeclampsia and 70 healthy controls matched for age, parity, and gestational age at enrollment. Venous samples were collected from each participant after informed consent was obtained. The preeclampsia group was further subdivided into mild and severe preeclampsia and all participants were followed up till delivery with records of delivery, maternal, and neonatal outcomes obtained thereafter. Serum CA125 levels were determined by standard enzyme-linked immunosorbent assay (ELISA) method. Hypothesis testing was done using chi-square test for categorical variables, and the independent-samples t-test and ANOVA for numerical variables. All significances were reported at P
Databáze: Directory of Open Access Journals
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