Pregnancy, perinatal and childhood outcomes in women with and without polycystic ovary syndrome and metformin during pregnancy: a nationwide population-based study

Autor: Romina Fornes, Johanna Simin, Minh Hanh Nguyen, Gonzalo Cruz, Nicolás Crisosto, Maartje van der Schaaf, Lars Engstrand, Nele Brusselaers
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Reproductive Biology and Endocrinology, Vol 20, Iss 1, Pp 1-12 (2022)
Druh dokumentu: article
ISSN: 1477-7827
DOI: 10.1186/s12958-022-00905-6
Popis: Abstract Background Polycystic Ovary Syndrome (PCOS) is an endocrine disorder that affects women in reproductive age and represents an unfavourable risk factor for several pregnancy and perinatal outcomes. Despite, no guidelines or pharmaceutical strategies for treating PCOS during pregnancy are available. The aim of this study is to determine the association between polycystic ovary syndrome with or without metformin and the pregnancy, perinatal outcomes as well as the risk of obesity in children born to these mothers. Methods In this nationwide population-based cohort study based in Swedish population, all singleton births (n = 1,016,805) from 686,847 women since 2006 up to 2016 were included. Multivariable logistic and Cox regression modelling with odds ratios (OR) and hazard ratios (HR) and 95% confidence intervals were used to study the association between the exposure of maternal PCOS, metformin during pregnancy (or the combination of both) and: 1) Pregnancy outcomes: preeclampsia, gestational diabetes, caesarean section, and acute caesarean section, 2) Perinatal outcomes: preterm birth, stillbirth, low birth weight, macrosomia, Apgar
Databáze: Directory of Open Access Journals
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