Evaluation of contemporary echocardiographic and histomorphology parameters in predicting mortality in patients with endomyocardial biopsy-proven cardiac AL amyloidosis

Autor: Efstratios Koutroumpakis, Adam Niku, Christopher K. Black, Abdelrahman Ali, Humaira Sadaf, Juhee Song, Nicolas Palaskas, Cezar Iliescu, Jean-Bernard Durand, Syed Wamique Yusuf, Hans C. Lee, L. Maximilian Buja, Anita Deswal, Jose Banchs
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Frontiers in Cardiovascular Medicine, Vol 9 (2023)
Druh dokumentu: article
ISSN: 2297-055X
DOI: 10.3389/fcvm.2022.1073804
Popis: IntroductionThis study examined the role of echocardiographic and cardiac histomorphology parameters in predicting mortality in patients with cardiac AL amyloidosis.MethodsPatients with endomyocardial biopsy-proven cardiac AL amyloidosis treated at MD Anderson Cancer Center between 6/2011 and 6/2020 were identified. Stored echocardiographic images and endomyocardial biopsy samples were processed for myocardial strain analysis and a detailed histomorphology characterization.ResultsOf 43 patients; 44% were women and 63% white. Median age was 65 years; 51% underwent stem cell transplantation (SCT). Thirty patients (70%) died during follow up (median follow up: 4.1 years). Lower LA strain (
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