In-situ proliferation contributes to the accumulation of myeloid cells in the spleen during progressive experimental visceral leishmaniasis.

Autor:	E Yaneth Osorio, Audrie A Medina-Colorado, Bruno L Travi, Peter C Melby
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Medicine Science
Zdroj:	PLoS ONE, Vol 15, Iss 11, p e0242337 (2020)
Druh dokumentu:	article
ISSN:	1932-6203
DOI:	10.1371/journal.pone.0242337
Popis:	Visceral leishmaniasis (VL) is characterized by expansion of myeloid cells in the liver and spleen, which leads to a severe splenomegaly associated with higher risk of mortality. This increased cellularity is thought to be a consequence of recruitment of cells to the viscera. We studied whether the local proliferation of splenic myeloid cells contributes to increased splenic cellularity. We found that a monocyte-like population of adherent splenic cells from Leishmania donovani-infected hamsters had enhanced replicative capacity ex vivo and in vivo (BrdU incorporation, p
Databáze:	Directory of Open Access Journals
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