Association study of a single nucleotide polymorphism in the hypoxia response element of the macrophage migration inhibitory factor gene promoter with suicide completers in the Japanese population

Autor:	Toshiyuki Shirai, Satoshi Okazaki, Takaki Tanifuji, Ikuo Otsuka, Masao Miyachi, Shohei Okada, Ryota Shindo, Tadasu Horai, Kentaro Mouri, Motonori Takahashi, Takeshi Kondo, Yasuhiro Ueno, Akitoyo Hishimoto
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	genetics: Human hypoxia inducible factor macrophage migration inhibitory factor single nucleotide polymorphism suicide: basic/clinical Therapeutics. Pharmacology RM1-950 Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Zdroj:	Neuropsychopharmacology Reports, Vol 44, Iss 1, Pp 262-266 (2024)
Druh dokumentu:	article
ISSN:	2574-173X
DOI:	10.1002/npr2.12410
Popis:	Abstract Background More than 800 000 people die by suicide annually. The heritability of suicide is 30%–50%. We focused on the hypoxia response element (HRE), which promotes the expression of macrophage migration inhibitory factor (MIF) via the hypoxia‐inducible factor (HIF) pathway, important in neurogenesis and neuroprotection. We examined a genetic polymorphism of rs17004038, a single‐nucleotide polymorphism (SNP), in suicide completers and controls. Methods The study population included 1336 suicide completers and 814 unrelated healthy controls. All participants were Japanese. We obtained peripheral blood, extracted DNA, and genotyped the patients for SNP rs17004038 (C > A). Results No significant differences were observed between the two groups in either the allele or genotype analyses. Subgroup analyses by sex, age (
Databáze:	Directory of Open Access Journals
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