Pyrimidine Acyclo-C-Nucleosides by Ring Transformations of 2-Formyl-L-arabinal
| Autor: | Klaus Peseke, Manfred Michalik, Holger Feist, Ahmed Bari |
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| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: | |
| Zdroj: | Molecules, Vol 10, Iss 8, Pp 837-842 (2005) |
| Druh dokumentu: | article |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/10080837 |
| Popis: | The protected 2-formyl-L-arabinal 2 reacted with thiourea and cyanamide in the presence of sodium hydride to afford via ring transformations the 5-[1R,2S-1,2- bis(benzyloxy)-3-hydroxypropyl]-1,2-dihydropyrimidines 3 and 4, respectively. Similarly, treatment of 2 with 3-amino-2H-1,2,4-triazole yielded 6-[1R,2S-1,2- bis(benzyloxy)-3-hydroxypropyl][1,2,4]-triazolo[1,5-a]pyrimidine (5). |
| Databáze: | Directory of Open Access Journals |
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