Clinical and epidemiological features of Berkitt's lymphoma
| Autor: | Elena Aleksandrovna Baryakh, Sergey Kirillovich Kravchenko, Aleksandra Mikhaylovna Kremenetskaya, Evgeniy Evgen'evich Zvonkov, Tat'yana Nikiforovna Obukhova, Aminat Umaraskhabovna Magomedova, Andrey Ivanovich Vorob'ev, E A Baryakh, S K Kravchenko, A M Kremenetskaya, E E Zvonkov, T N Obukhova, K U Magomedova, A I Vorobyev |
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| Jazyk: | ruština |
| Rok vydání: | 2009 |
| Předmět: | |
| Zdroj: | Терапевтический архив, Vol 81, Iss 7, Pp 47-53 (2009) |
| Druh dokumentu: | article |
| ISSN: | 0040-3660 2309-5342 |
| Popis: | Aim. To characterize clinical and epidemiological features of adult Berkitt's lymphoma (BL). Material and methods. The trial enrolled 72 patients (51 males and 21 females, age 14-69, mean age 27 years) treated in 1995-2008. Results. Stage I BL (by S.B. Murphy) was diagnosed in 5 patients, stage II - in 9, stage III - in 25, IV - in 14 patients, B-cell acute lymphoblastic leukemia (ALL) (L3) - in 19 patients. Intoxication was seen in 56(78%) patients, 38% patients had severe cachexia. Elevated concentration of lactatedehydrogenase (LDG) was detected in 57(79%) patients. In all the cases clinical symptoms developed for 1-3 months, median 6 weeks. Bone marrow involvement was diagnosed in 22 (31%) patients, CNS was affected in 17(24%) patients, of them 14 were males. Fifty two (72%) patients had abdominal, retroperitoneal and/or small pelvis tumors. Intestinal, hepatic, renal and gastric tumors occurred most frequently. Specific ascitis was detected in 25(48%), tumor pleuritis - in 11(15%) patients. BL of the facial skeleton, Waldeyer's ring, oro- and nasopharynx was in 12(17%) patients. Seven patients had concomitant involvement of the CNS. Eight (38%) and 2(10%) women had tumors of the ovaries and uterus, respectively. Conclusion. BL is characterized by the following clinical features: young age of the patients, most of them are males, B-symptoms, short history, generalized stages, extranodal lesions, frequent involvement of the bone marrow and CNS. |
| Databáze: | Directory of Open Access Journals |
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