| Autor: |
Lidy Vannessa Mejía-Guarnizo, Paula Stefanny Monroy-Camacho, Daniel Esteban Rincón-Rodríguez, Andrés Rincón-Riveros, Daniel Augusto Martinez-Vargas, Carlos Alexander Huertas-Caro, Ricardo Oliveros-Wilches, Ricardo Sanchez-Pedraza, Marcela Nuñez-Lemus, Carlos Felipe Cristancho-Lievano, Adriana Milena Castellanos-Moreno, Lina María Martinez-Correa, Josefa Antonia Rodríguez-García |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-023-40132-6 |
| Popis: |
Abstract Gastric cancer (GC) is the fifth most frequent malignancy worldwide and has a high mortality rate related to late diagnosis. Although the gold standard for the GC diagnosis is endoscopy with biopsy, nonetheless, it is not cost-effective and is invasive for the patient. The Human leukocyte antigen G (HLA-G) molecule is a checkpoint of the immune response. Its overexpression in cancer is associated with immune evasion, metastasis, poor prognosis, and lower overall survival. We evaluate the plasma levels of soluble HLA-G, (sHLA-G) in patients with GC and benign gastric pathologies using an ELISA test. A higher concentration of sHLA-G in patients with GC than in those with benign pathologies, higher levels of plasma sHLA-G in women with GC compared with men and significant differences in the sHLA-G levels between the benign gastric pathologies evaluated, was our main findings. As no significant differences were found between the GC assessed stages in our study population, we suggest that sHLA-G is not an adequate marker for staging GC, but it does have diagnostic potential. In addition to providing information on the potential of sHLA-G as a diagnostic marker for GC, our study demonstrate that HLA-G molecules can be found in the membrane of exosomes, which highlights the need to perform studies with a larger number of samples to explore the functional implications of HLA-G positive exosomes in the context of gastric cancer, and to determine the clinical significance and possible applications of these findings in the development of non-invasive diagnostic methods. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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