Association Between the Early Discontinuation of Durvalumab and Poor Survival in Patients With Stage III NSCLC

Autor: Narek Shaverdian, MD, Michael Offin, MD, Annemarie F. Shepherd, MD, Matthew D. Hellmann, MD, Daniel R. Gomez, MD, Jamie E. Chaft, MD, Andreas Rimner, MD
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: JTO Clinical and Research Reports, Vol 2, Iss 7, Pp 100197- (2021)
Druh dokumentu: article
ISSN: 2666-3643
DOI: 10.1016/j.jtocrr.2021.100197
Popis: Introduction: Durvalumab after concurrent chemoradiation (cCRT) has been found to improve outcomes of patients with unresected stage III NSCLC. However, the survival impact of discontinuing durvalumab early owing to adverse events (AEs) remains unknown. Methods: Patients with stage III NSLCC treated with cCRT and greater than or equal to one dose of durvalumab across a multisite cancer center were evaluated. The median durvalumab treatment duration among patients who discontinued owing to AEs (2.1 mo) defined two patient cohorts: early discontinuation (
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